What is the dosage of Amiodarone after the third defibrillation attempt for shockable rhythms?

In cases of cardiac arrest due to shockable rhythms, such as ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT), Amiodarone is an antiarrhythmic medication that is administered to help stabilize the heart's rhythm. After the third defibrillation attempt, the recommended dosage of Amiodarone is 300 mg. This high initial dose is given to increase the likelihood of successful defibrillation and to manage the arrhythmia effectively.

The rationale behind administering a higher dose after multiple failed attempts is that the heart may be increasingly resistant to previous shocks, and a more substantial pharmacological intervention like this may improve outcomes by addressing the underlying rhythm disturbance. Subsequent doses of 150 mg may be given for further treatments, but for the third attempt, the 300 mg dosage is the standard practice in advanced life support protocols. This approach is guided by evidence-based guidelines from resuscitation councils worldwide.